Abstract

Abstract

Background: Kayachikitsa, the core discipline of Ayurveda dealing with internal medicine, emphasizes systemic balance through regulation of Doshas, Agni, Dhatus, and Malas. With the global rise in chronic non-communicable diseases, there is increasing scientific interest in Ayurveda as a preventive and therapeutic system. Objective: To critically evaluate recent advancements in Kayachikitsa with focus on clinical applications, pharmacological validations, personalized medicine, and technological integration, while proposing paths for future research. Methods: A comprehensive narrative review was conducted using classical Ayurvedic texts and contemporary peer-reviewed literature. Data from institutional reports and recent experimental and clinical studies were also analyzed to identify emerging trends and research gaps. Results: There are key evidences which indicates that Kayachikitsa-based interventions improve metabolic parameters in lifestyle disorders. Advances in phytochemistry have identified various bioactive compounds which have multi-targeted actions. Emerging fields such as Ayurgenomics and digital health integration are reshaping personalized care. However, limitations are present in methodological standardization and translational research. Conclusion: Kayachikitsa holds strong potential as a systems-based medical approach. Future progress depends on integrative research models, biomarker-driven validation, and incorporation of emerging technologies such as metabolomics and artificial intelligence.