Abstract

Abstract

Introduction: The gut–skin axis is an emerging concept in modern medicine that highlights the bidirectional relationship between gastrointestinal health, immune regulation, and dermatological conditions. Ayurveda, though not using this terminology, describes a similar interconnection through the principles of Agni, Ama, Rasa–Rakta, and Dooshivisha.

Methods: This study is a conceptual review based on classical Ayurvedic texts and contemporary scientific literature. Google scholar, researchgate, pubmed,etc databases were used to gather information. The modern understanding of the gut–skin axis was analyzed and correlated with Ayurvedic principles, with special reference to the toxicological concept of Dooshivisha. Results: Impairment of digestive fire leads to the formation of Ama, a toxic metabolic by-product that obstructs bodily channels and vitiates Doshas. This results in Rasa and Rakta Dushti, ultimately manifesting as skin disorders. Chronic accumulation of toxins resembles Dooshivisha, explaining the persistence and recurrence of dermatological conditions. Modern concepts such as gut dysbiosis, increased intestinal permeability, systemic inflammation, and immune dysregulation show strong parallels with Ayurvedic pathophysiology. Conclusion: This integrative perspective provides a holistic framework for understanding the etiopathogenesis of chronic dermatological disorders and emphasizes the importance of digestive health, toxin elimination, and systemic balance in their management.