Correspondence Address:
Dr.Sandeep Kisan Rajput- Associate Professor Balrog Department YMT Ayurved College and Hospital, Kharghar E-mail – dr.rajputsandeep@gmail.com
Date of Acceptance: 2021-04-20
Date of Publication:2021-05-01
Article-ID:IJIM_68_05_21 http://ijim.co.in
Source of Support: NIL
Conflict of Interest: NIL
How To Cite This Article: Rajput SK., Irole SA, Nandekar S, Pawar U. Systemic Review Of Kaval Drugs Against Oral Care W.S.R. To Ashtang Hrudaya.Int. J Ind. Med. 2021;2(4):9-19
Oral health is related to general health of human, mouth is mirror of general health. Oral health problems are increases day by day in world wide. In day today life oral cavity is exposed to external environmental pollutions, cold drinks, smoking, chewing tobacco and alcohol intake, so oral health problems are increasing. Therefore to maintain the oral health Ayurveda introduces to procedures is Kaval.Taking lesser amount of medicated fluid which can be move in the mouth is called Kaval. This procedure makes jawbone strengthens. It enhances interest in food. It makes tine sweet n sharp. It reduces the cracks on lips. It avoids dryness of throat and mouth. Oral diseases continue to be major health problem world wild there for it is very important to maintain oral hygiene for maintenance of health and longevity of human Being in particular age group .
Keywords: Kaval, Gandush, oral health, mouth. Stomatitis
Ayurveda is an Ancient Science and holistic system of medicine which evolved in Indian some 3000-5000 years ago, a system of traditional native to the Indian Subcontinent.(1) The Sushrut Samhita and Charak Samhita are its earliest authorize text.(2)Over the centuries , Ayurvedic Practitioners developed large numbers of medicinal preparations.(3)The main aim of Ayurveda is to preserve the healthy person remains as healthy and also treat or cure the person who is suffered from any diseases in such way that the disease is snatch away from its root cause.(4)Ayurveda gives prime importance to "Swasthya Samrakshana".So, Ayurveda explains some vidhi ( procedure ) mainly used as a preventive aspects like Dincharya, Ratricharya, Ritucharya, Sadvritta, Achar Rasayan etc. So such routine has helped to maintain the health of the person. There are various methods for maintaining oral hygiene which is explained in Ayurvedic text. Methods includes such as Dantdhavan (tooth brushing) pratisaran ( local application) , jivha nirlekhan (tongue scraping), kaval. Among this kaval and gandush have more efficacy to maintain oral health.(5.6) The techniques which should follow on daily bases is called ”Dincharya”.In Ayurveda Gandush and Kaval are explained as one of the routine procedure under the context of daily regimen (Dincharya)(7,8) for the maintenance of good oral health. It can be done in both healthy and disease person. Gandush and kaval are the two specific therapies for cleaning the mouth. In Gandush you fill the liquid or oil in the mouth fully so there is no movement in your mouth and so your mouth is completely distend, and it is held until there is lacrimation, nasal discharge and then patient is spit this out. This process is very good for teeth and it vanishes all the impurities and toxins, it stretches your check muscles therefore several reasons why you do that.(9) Kaval is a process where you take oil or liquid in your mouth and movement around and gargle it all the way to back of throat for specific amount of time.(10)The difference between the two is only in the composition of drugs, dosage and procedure of using the drug.
We are tried to review the various Kaval drugs and its benefits as well as action on oral disease of oral cavity. So there are many formulations for kaval and are available in Ayurvedic text, we are focusing on only 2 formulations which are explained in Ashtang Hridaya.
Aims- To evaluate Doshagana Properties in formulation of Kaval.
Objective – To find out the drug efficacy with the help of their properties like Rasa Virya Vipak
Material and Methods
Schedule for kaval : The 3/4th medicated fluid or medicated paste is kept in mouth with concentrated mind along with swiss movement till the collection of kapha in mouth(11)
Indication for kaval: Shiro rog ( disease of head ), manya roga ( disease of neck ) mukha roga ( disease of lips , teeth, gums , tongue, soft palet , pharynx larynx ) , Akshi roga ( disease of eye ) , karna roga ( disease of ear) praseka ( excessive salivation ), kantha roga ( disease of throat ) , vaktrashosh ( dryness of mouth ), hrullas ( nausea ), Tandta ( stupor), aruchi ( anorexia ) pinasa ( rhinitis ) , are specially by kaval .(12)
Benefits of kaval : Swarabhed ( strength of voice ), hanubalam ( strength of jaws ), strength of face, better teast perception , strong & healthy teeth, Resistance again Doshaja or Agantuja Mukharog , (13)
Samyak lakshana of kaval : vyadhiapachaya ( disease subside ) Trushti ( feeling of freshness ) Vaishadya ( cleansing effect ) Vaktralaghuta ( lightness of mouth ) , Indriyaprasada ( clarity of sense Organ ) (14)
Hinayoga lakshana of kaval : stiffness, excitation of kapha , loss of test (15)
Atiyog lakshana of kaval : mukhapak ( stomatitis ), sosa ( dryness of mouth ) , Trushna ( thirst ) arucchi ( anorexia ) , klama ( exhaustion ) (16)
Formulation 1: Ashtang hridaya; Uttar tantra, 22/97. The ingredients of 1st formulation: Kantkari, Guduchi, Chameli, Daruharidra, Jawasa, Triphala, Madh (17).
Formulation 2: Ashtang hridaya; Uttar tantra, 22/103. The ingredients of 2nd formulation: Saptaparna, Ushir, Patol, Mustha, Haritaki, Kutki, Madhuyashi, Amlatas, Chandan (18).
OBSERVATION -
FORMULATION: 1
1. KANTKARI: Kantkari is belongs to Solanaceae family and which is include in Dashmool and commonly used in Ayurveda. Dashmool is an important compound formulation of Ayurveda has been advocated with promising result in various diseases.(19)Kantkari is mostly used in Respiratory diseases in Ayurveda.(20)The plant is useful in Fever, Cough, Asthma etc.(21) Vedanasthapana (pain reliever), Shothahara (reduces swelling), Swedajanana (increases sweating), Jwaraghna (Anti-pyretic), Deepana ( appetizer), Pachana (digestive), Rechana (purgative), Bhedana, Krimighna (anthelmintic), Amadoshanashaka (indigestion), Raktashodhaka (blood purifier), Kasahara (relieves cough), Shwasahara ( Asthma ), Kanthya ( throat ), Hikkanigrahana (anti-hiccups) , are the therapeutic activities of kantakari.(22)
2. GUDUCHI: Guduchi mentioned in Ayurvedic text of Ayurvedic system of medicine like Charak, Sushrut, Ashtang Hridaya and other varies text like Bhavprakash, Dhanvantari Nighantu. (23, 24) Tiktaa- saka varga (vegetables) and claimed to be useful in treating fever, asthma, anorexia. (25) Indicated in fever, gout, jaundice. (26,) Skin infections, chronic diarrhoea, and dysentery like G.I.T infection. (27) To cure bleeding piles, curing itching, erysipelas. (28)
Guduchi mainly contains alkaloids, glycosides, steroids, sesquiterpenoids, aliphatic compounds, essential oils, mixture of fatty acids and polysaccharides. The alkaloids include berberine, bitter gilonin, non-glycoside gilonin gilosterol. (29)
3. CHAMELI: Leaves are chewed in a stomatitis, toothache, ulcer in the mouth and leaf-juice or oil obtained from it is dropped into the ear (30). A decoction of the leaf was also used as a gargle (31). The plant is bitter, astringent, acrid, thermogenic, aphrodisiac, antiseptic, anodyne, depurative, emollient, diuretic, anthelmintic, deobstruant, dentifrices, suppurative and tonic(32)
4. DARUHARIDRA: Berberis aristata DC . Commonly knowns as Daruharidra are a popular drug which has been used globally. Charak Samhita prescribed that the extract of the plant be taken internally for treatment of hemorrhage, piles, pruritus, shotha (Inflammation), eye disease and alopecia. Described it as being useful internally in indigestion, deficiency of breast milk, and in uterine and vaginal disorders. (33) Treat allergies, metabolic disorders, ophthalmic, and other eye diseases, treat bleeding piles, anti-osteoporosis, treat skin diseases, menorrhagia, fever, diarrhea, dysentery cholera, jaundice, ear infections, anti-bacterial, anti-fungal, anti-inflammatory analgesic, anti-pyretic, anti-diabetic, and anti-hepatopathic (34)
5. JAVAS: Javas have Antimicrobial(35) , expectorants(36), inflammatory , antipyretic activity.(37) Pharmacological activity Rheumatism, bronchitis, ulcers, liver disorders and jaundice, asthma and gallbladder problems, antibacterial, antifungal, antioxidant, antiproliferative, hepatoprotective spasmolytic and ureter-relaxing effects(38) .
6. TRIPHALA:
a) AMLA: Pharmacological activity on amla: Antioxidant (39) hypoglycemic, anti-inflammatory, Antihyperglycemic, Antihyperlipedemic,(40,) antipyretic, analgesic, antitussive, antiatherogenic, adaptogenic, cardioprotective, gastroprotective, antianemic, anti-hypercholesterolemia, wound healing, anti-atherosclerotic, hepatoprotective,. In addition, experimental studies have shown that amla and some of its phytochemicals such as Gallic acid, ellagic acid, pyrogallol, some norsesquiterpenoids, corilagin, geraniin, elaeocarpusin, and prodelphinidins B1 and B2 also possess antineoplastic effects. Amla is also reported to possess radio modulatory, Antimutagenic effects decreases lipid peroxidation decreases ornithine decarboxylase radio protective agent chemo preventive agent (41).
b) BIBHITAK: Pharmacological effects as follows: Analgesic activity (42), Antihypertensive effect (42), Antispasmodic and Bronchodilator properties (43), Antimicrobial activity (44) Antioxidant activity (45), wound healing activity (46), immunological activity (47), Acute – subacute toxicities (48) Hepatoprotective activity (49),
c) HARITAKI: Haritaki is used to treat Ophthalmic, itching, edema (50) it is used as an Antioxidant and neuroprotective drug (51). This plant is also used for treating piles, dropsy, diarrhoea, biliousness, headaches, dyspepsia and ascites [52].It is also used for heart disease, inflammation, brain dysfunction [53] .
7. MADH:Pharmacological Effects: Madh have antioxidant activity (54), Antimicrobial activity (55), Antifungal effect, Antiviral activity (56), Anti-inflammatory activity (57).
FORMULATION 2 :
1. SAPTAPARNA: It is useful in abdominal disorders, fevers, leprosy, skin diseases, chronic and foul ulcers, asthma, bronchitis and helminthiasis. It is used to treat diarrhoea (67) wound and earache (68) The plant have antioxidant activity (69) antiproliferative activity (70) anticarcinogenic and antimutagenic activity (71)
2. USHIR : Ushir is used to treat mouth ulcers, headache, malaria, fever, acidity, boil, burn, epilepsy, inflammation.(72) Varnya (complexion or color of skin ) , Stanyajanan (galactogogue) , Chardinighraha ( Antivomiting ) , Dahaprashaman ( cooling agent ) , Pittasanshaman , Swedopanayan ( that substance over sweating of body ). (73)
3. PATOL: Pharmacological activity : Patol have chemo preventive activity, Antihyperglycemic and Antihyperlipedemic activity, laxative activity, anti-inflammatory and anti-nociceptive activity, cholesterol lowering activity.(74)
4. MUSTHA: Pharmacological effects: Mustha have Anti-inflammatory activity (75), wound healing activity (76), antimicrobial activity (77), anticonvulsant activity (78), hepatoprotective activity (79), anti-obesity activity (80) Antidiabetic activity (81) antioxidant activity (82), antiplatelet activity (83) antimalarial activity (84).
5. HARITAKI: As mentioned in formulation 1
6. KUTKI: Kutki is used as medicine for cough, cold; fever (85).It is used to cure jaundice, diarrhoea and dysentery. (86) Pharmacological activity: Kutki have Antimicrobial activity (87), antibacterial activity (88), cytotoxicity, anti-mutagenic activity (89), nephroprotective activity (90), anti-inflammatory activity (91), and antioxidant activity (92).
7. MADHUYASHTI: Pharmacological activities of Yastimadhu are demulcent, expectorant, anti-allergic, anti-inflammatory, spasmolytic, mild laxative, anti-stress, anti-depressive, antiulcer, liver protective, estrogenic, and anti-diabetic. It is widely used in bronchitis, dry cough, respiratory infections, catarrh, tuberculosis; genitourinary diseases, urinary tract infections; abdominal pain, gastric and duodenal ulcers, inflamed stomach, mouth ulcer; and for adrenocorticoid insufficiency.(93)
8. AMLATAS: Pharmacological activities of Amlatas are anti-inflammatory (94) antioxidant (95), antidiabetic (96) as well as hepatoprotective activity (97).Antioxidant (98) Antipyretic (99)
9. CHANDAN: Chandan is used as a medicine in diarrhoea with bleeding, intrinsic hemorrhage, bleeding piles, vomiting, poisoning, hiccoughs, urticarial , eye infections and inflammation of umbilicus.[100, 101] Chandan is mostly used as a Diuretic (102) and in urinary infection (103)Chandan and its bark possessed abortifacient, hepatoprotective, urinary antiseptic, stomachic, anti-viral and anti-herpetic activities.[104]
Mode of action Kavala
The saliva consists of lysozyme, an enzyme and antibody IgA, which are bacteriostatic and antimicrobial in nature. The Gandush and Kavala increase the pressure in the mouth, which stimulates the stretch reflex i.e. the presso receptors resulting in stimulation of the salivary nuclei in brain stem. This results in increased activity of parasympathetic motor fibers of facial and glossopharyngeal nerves and increases the salivary output, which is further stimulated by the chemical constituents stimulating the oral chemo receptors and hence the Gandush and Kavala maintains and cures the oral environment.[113]
Table no, 1
Table 2
Formulation 1: The entire drug in this formulation acts on Respiratory tract infection. The drugs having Antiseptic, anti-oxidant anti-inflammatory properties. Mostly they are Kapha dosha dominant, they have Ushna, Virya, Laghu and Ruksha properties according to Ayurveda. These drugs are Kapha dominants so mostly used in Urdhwajatrugat Vikar upper respiratory tract infections.
Formulation 2: All the drugs in this formulations having antioxidant, wound healing, anti-inflammatory properties. They act on Fever, URTI, and Bleeding disorder. Maximum drugs are shit Virya, Tiktaa and Madhur ras and Madhur Vipak so they mostly act on piitaj vikar.
Above formulations are based on dosh samprapti. So according to Doshaghnata we can use the drugs. This is our small efforts how these drugs will be act by their Doshaghnata as well by their qualities. Simple and economical procedure to preserve positive health as well as cures the disease of the person . bioactive ingredients present in the drug.
1.Oil pulling for maintaining oral hygiene e A review Vagish Kumar L. Shanbhag*.Journal of Traditional and Complementary Medicine, 2017; 7: 106e109. journal homepage: http://www.elsevier.com/locate/jtcme.
2. Chopra, Ananda . Berlin, Heidelberg: Kluwer Academic Publishers; 2003. Medicine Across Cultures: History and Practice of Medicine in Non-Western Cultures. [Google Scholar]
3. Dwivedi G, Dwivedi S. History of Medicine: Sushruta – the Clinician – Teacher par Excellence. Indian J Chest Dis Allied Sci. 2007;49:243–4. [Google Scholar]
4. Prevention and treatment of diseases of mouth by gandoosh and kavalusujatasooryavanshi and b. r. mardikarbharatividyapeeth’s college of ayurveda, erandwane, pune – 411 038, india
5.K.R.Srikanthamurthy, Astanga Hrdayam, Sutrasthana, Dinacharyaadhyayam, Chowkhamba Krishnadas Academy. 2.
6.Agnivesha. Charaka Samhita, Comm. Chakrapanidatta. In: Jadavaji TA, editor. Sutrasasthana. Varanasi: Chaukhamba Surbharati Prakashana, 2008. 5/78-81: 27
7. Aspalli S, Shetty VS, Devarathnamma MV, Parab P. J Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial.: Indian SocPeriodontol. 2014 Jan;18(1):48- 52.PMID: 24744544
8. Pradeep AR, Suke DK, Triphala, a New Herbal Mouthwash for the Treatment of Gingivitis: A Randomized Controlled Clinical Trial. Periodontol. 2016 Nov; 87(11):1352-1359. Epub 2016 Jul 21.; PMID: 27442086
9. Ambika datta. SushrutaSamhita, Vol-1, CHIKISTA STHAN 40/62, Chaukhambha
10. Asthang hrudhah sutrasthan 22/1, Tripathi Ravidutt.
11.P.V.Sharma, Susruta Samhita, volume 2 Chikitsa sthana, (40): 62. Chaukhambha Visvabharati, Varanasi.
12. Priya VratSharma, Susruta Samhita, volume 2 Chikitsa sthana, (40): 60-61. Chaukhambha Visvabharati, Varanasi.
13. critical analysis of role of kaval and gandush in the management of halitosis krithi amai1 www.jahm.in (ISSN-2321-1563)
14. International Journal of ayurvedic medicine http://iijam.co.in ISSN:0976-5921 , 2014,5(2),148-153.
15. Priya VratSharma, Susruta Samhita, volume 2 Chikitsa sthana, (40): 63. Chaukhambha Visvabharati, Varanasi.
16. Priya VratSharma, Susruta Samhita, volume 2 Chikitsa sthana, (40): 64. Chaukhambha Visvabharati, Varanasi.
17. Pt. Shastri Kashinath,Ashtang Hridaya,Krishnadas Academy Varanasi chaukumba press, edition 1994, 22/97 Pp-522.
18. Pt. Shastri Kashinath,Ashtang Hridaya,Krishnadas Academy Varanasi chaukumba press, edition 1994, 22/103 Pp-523.
19.Sharma PV. Dravyaguna vijnana, Vol.1. Varanasi: Chaukhamba Bharati ; 2006.p. 125.
20. Chunekar KC, Pandey GS. Bhavaprakasha Nighantu. 10 th ed. Varanasi: Chaukhamba Bharati Academy; 1999. p.290-292.
21. Nadkarni KM. Indian Materia Medica, Vol.-I. 3RD ed. Mumbai: Popular Publication; 2009.p.1156-1158.
22. Anonymous. The Ayurvedic Pharmacopoeia of India, Part-I, Vol. I, 1st. ed. New Delhi: Govt.of India, Ministry of Health and Family Welfare, Dept. of I.S.M. & H.; 2001.p.59-60.
23.Mitra R., Raghunandan K. Anonymous, Pharmacognosy of Indigenous Drugs Vol. 1; (Central Council for Research in Ayurveda & Siddha, New Delhi) 1982: 321.
24.Vaagbhata, Ashtanghridayaam, Commentary by Arunadatta & Hemaadri, collected by Kunt & Narvare and Edited by Paradkara, (Chaukhambha Orientalia, Varanasi & Delhi), 1982.
25..Sushruta, Sushruta Samhita, commentary by Dalhana, Edited by Jadavji Trikamji Acharya, (Chaukhambha Orientalia, Varanasi & Delhi), 1992.
26.Charka, Charaka Samhita, Part I & II, (Hindi commentary by Pandey & Chaturvedi), Edited by Rajeshwar Datta Shastri, (Chaukhambha Vidyabhawan, Varanasi), 1961.
27.Misr.a B. Bhava Prakash Nighantu, Vol. 1, (Hindi commentary by K C Chunekar), (Chowkhamba Vidya Bhavan, Varanasi), 1969: 269.
28. Aiyer K N; Kolammal M. Pharmacognosy of Ayurvedic Drugs of Kerala, (Central Research Institute Trivendrum) 1963; 1:28
29.The Wealth of India, Raw Materials; Publication & Information Directorate, Council of Scientific & Industrial Research: New Delhi 1982; 10: 252
30. Panda H. Herbs cultivation and Medicinal uses. New Delhi: National Institute of Industrial Research, 2000: 324.
31. Khare CP. Encyclopedia of India Medicinal Plants, Rational Western Therapy, Ayurvedic and other traditional Usage. New York: Springer-Verlag Berlin Heidelberg, 2007: 267-68.
32. Warrier PK, Nambiar VPK, Ramankutty. Indian Medicinal Plants- a Compendium of 500 Species. Vol. 3. Chennai: Orient Longman Pvt Ltd, 2004: 249-253.
33. Sharma P, Samhita C. Chaukhambha Orientalia. Varanasi: 1992. p. 2. Su.4.3, 12.14, Ci. 6.26, 28. [Google Scholar]
34. Fronties in pharmacology Maria. A. Neag 21 august 2018 volume 91 Articles 557 Neag.etal doi10.3389/fphar.2018.00557 www.frontiersin.org
35.Laghari, Abdul Hafeez; Memon, Shahabuddin; Nelofar, Aisha; Khan, Khalid M. Determination of Volatile Constituents and Antimicrobial Activity of Camel Thorn (Alhagi camelorum) Flowers; Volume 47, Number 3, 2014, pp. 413-421(9)
36.Khare CP, Indian medicinal plant, 2nd ed., Springer publication, New Delhi, 2007, pp. 24-40.
37.Amani S. awaad, Meligy R.M.H, Qenawy S.A. Antiinflammatory, antinociceptive and antipyretic effects of some desert plants, Alhagi maurorum Medic. journal of saudi chemical society . 15; issue 2011, Oct: [Internet] Available from: www.sciencedirect.com.
38.M.S. Marashdah, H.M. AL-Hazimi; Pharmacological activity of ethanolic extract of Alhagi Maurorum roots; Arabian Journal of Chemistry (2010)3,39–42.
39.V.D. Reddy, P. Padmavathi, G. Kavitha, S., Emblica officinalis ameliorates alcohol-induced brain mitochondrial dysfunction in rats,J. Med. Food 14 (1–2) (2011) 62–68
40.B.Antony, M. Benny I.N.B.Kamal A Pilot Clinical study to evaluate the effect of Emblica officinalis extract (Amlamax™) on markers of systemic inflammation and dyslipidemia, Indian J. Clin. Biochem. 23 (4) (2008) 378–381.
41.Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. European Journal of Cancer Prevention 2011, Vol 20 No 3 , Page No. 215-230
42. Arif-Ullah Khan, Anwarl Hassan Gilani. Pharmacodynamic Evaluation of Terminalia belerica for its Anti-Hypertensive Effect. Journal of Food and Drug Analysis. 2008; 16:6-14
43. Anwarul Hassan Gilani, Arif-Ullah Khan, Tuba ali. Anti-Spasmodic and Bronchodilatory Properties of Terminalia belerica Fruit, Journal of Ethnopharmacology. 2008; 116:528-538.
44. Elizabeth KM. Anti-microbial Activity of Terminalia belerica. Indian Journal of Clinical Biochemistry. 2005; 20(2):150-153.
45. Ramesh Kumar, Chauhan PK, Bhardwaj VS, Anu Kumar Munish kumar. In vitro investigations of antioxidant and phytochemical activities of aqueous extracts of Terminalia belerica & Terminalia chebula International Journal of Research in Pharmaceutical and Biomedical Sciences.
46. Saha PK, Patrab PH, Pradhan R, Radharaman Dey, Shyamal Das, Mandal TKV. Effect of Terminalia belerica & Terminalia chebula on wound healing in induced dermal wounds in Rabbits. Pharmacology online 2011; 2:235-241.
47. Aurasorn Saraphanchotiwitthaya, Pattana Sripalakit and Kornkanok Ingkaninan. Effects of Terminalia belerica Roxb. Methanolic extract on mouse immune response in vitro, Maejo International Journal of Science and Technology. 2008; 02(2):400-407.
48. Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninam K. Acute and Sub-acute Toxicities of the Ethanol Extract of fruit of Terminalia belerica Journal of Pharmacuetical sciences, 2009.
49. Pinmai K,. Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells. World J Gastroenterol. 2008; 14(10):1491-97.
50. Chia Lin Chang and Che San Lin, Phytochemical Composition, Antioxidant Activity and Neuroprotective Effect of Terminalia chebula Retzius Extracts, EvidenceBased Complementary and Alternative Medicine , Volume 2012, Article ID 125247, 7 pages
51. Pulliah T, Encycllopedia of world Medicinal Plants, Volume 4, Regency Publications, New Delhi, India, Pg.1931-1934.
52. Simran Kaur , Grover IS, Majar Singh , Antimutagenicity of hydrolyzable tannins from Terminalia chebula in Salmonella typhimurium, Mutation Research, 419, 1998, 169–179.
53. Chia-Lin Chang, Che-San Lin, Development of antioxidant activity and pattern recognition of Terminalia chebula retzius extracts and its fermented products, 2010.
54. B. Halliwell and J. M. Gutteridge, “Lipid peroxidation: a radical chain reaction,” Free Radical Biology & Medicine, vol. 2, pp. 188–218, 1989
55. Z. H. Israili, “Antimicrobial properties of honey,” American Journal of Therapeutics, vol. 21, no. 4, pp. 304–323, 2014.
56.R. J. Whitley, D. W. Kimberlin, and B. Roizman, “Herpes simplex viruses,” Clinical Infectious Diseases, vol. 26, no. 3, pp. 541–553, 1998.
57. L. Vandamme, A. Heyneman, H. Hoeksema, J. Verbelen, and S. Monstrey, “Honey in modern wound care: a systematic review,” Burns, vol. 39, no. 8, pp. 1514–1525, 2013.
58. Dr. Krushnachandra Chunekar, Bhavprakash Nighantu, page no.290, Chaukhambha Visvabharati, Varanasi,Reprint -2006
59. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 761, Chaukhambha Visvabharati,Reprint 2013
60. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 90, Chaukhambha Visvabharati,Reprint 2013
61. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 537, Chaukhambha Visvabharati,Reprint 2013
62. Dr. Krushnachandra Chunekar, Bhavprakash Nighantu, page no.652, Chaukhambha Visvabharati, Varanasi,Reprint -2006
63. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 753, Chaukhambha Visvabharati,Reprint 2013
64. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 758, Chaukhambha Visvabharati,Reprint 2013
65. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 239, Chaukhambha Visvabharati,Reprint 2013
66. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 202, Chaukhambha Visvabharati,Reprint 2013
67. Khyade MS, Kasote DM and Vaikos NP: Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, Phytochemistry and Pharmacology, Journal of Ethnopharmacology 2014; 153: 1-18.
68. Singh H, Arora R, Arora S and Singh B: Ameliorative potential of Alstonia scholaris (Linn.) R. Br. against chronic constriction injury-induced neuropathic pain in rats. BMC Complementary and Alternative Medicine 2017; 17(63): 1-9.
69. Mistry D, Bhavika P and Meonis P: Studies on phytochemical constituents and antioxidant activity of Alstonia scholaris. International Journal of Life Sciences 2016; 4(4): 529-38.
70. Wang CM, Yeh KL, Tsai SJ, : AntiProliferative Activity of triterpenoids and sterols isolated from Alstonia scholaris against non-small-cell lung Carcinoma cells. Molecules 2017, 22: 1-13.
71. Ahmad MS, Ahmad S, Ali : Anticarcinogenic and antimutagenic activity of Alstonia scholaris on the albino mice bone marrow cells and peripheral human lymphocyte culture against methyl methane sulfonate induced genotoxicity. Advanced Biomedical Research 2016; 5(1): 1-11.
72. Satya Praksh Singh et al., Review on Vetiveria zizanoides: A medicinal herb, Journal of drug discovery and therapeutics, Vol.1, Issue 7,2013, page 80-83.
73. Madhavi H Rabadia an international journal of pharmaceutical sciences Jagruti et al./pharma science Monitor 5(2) sup-1, Apr-Jun2014, page 365-373 impact factor 0.3397/ICV:4.10 https://www.researchgate.net/publication/289503555
74. Gupta vikas,Pagoch S S,Pharmacological review of Trichosanthes Dioica (patola), International journal, ISSN:2320 5091, Volume 2, Issue 3, May –June 2014
75.BiradarAnti-inflamatory, Analgesic & Anti convulsant activity of Cyperus essential oils. International Journal of Pharmacy & Pharmaceutical Sciences. 2010; 2(4):P.112-115.
76.Puratchikody A, Nithya Devi C, Nagalakshmi G, Wound healing activity of Cyperus rotundus linn, 2006; 68(1), 97-101.
77.Surendra Kumar Sharma, Ajay Pal Singh, Antimicrobial investigations on rhizomes of Cyperus rotundus Linn. Der Pharmacia Lettre, 2011; 3(3): 427-431.
78.Shivakumar SI, Suresh HM,Hallikeri CS, Hatapakki BC, Handiganur JS, Kuber Sankh, Shivakumar B, Anticonvulsant effect of Cyperus rotundus Linn rhizomes in rats, Journal of Natural Remedies, 2009; 9(2): P. 192-196.
79.Suresh Kumar SV, Mishra SH, Hepatoprotective Activity of Rhizomes of Cyperus rotundus Unn against Carbon tetrachloride-induced Hepato-toxicity, Indian J. Pharm. Sci, 2005; 67(1):P. 84-88.
80.Athesh K, Divakar M, Anti-Obesity Potential Of Cyperus Rotundus L. Aqueous Tuber Extract In Rats Fed On High Fat Cafeteria Diet,Asian J Pharm Clin Res, 2014; 7(2): P. 88-92.
81.Nishikant A Raut, Naresh J Gaikwad, Antidiabetic Potential of Fractions of Hydro-Ethanol Extract of Cyperus rotundus L. (Cyperaceae), RJPBCS, 2012; 3(4).P. 1014-1017.
82.Yazdan parast R, Ardestani A. In vitro Anti oxidant and free radical scavenging activity of Cyperus rotundus, Journal of Medicinal Food. December 2007; 10(4): 667-674.
83.Eun Ji Seoa, Dong-Ung Leee, Jong Hwan Kwakf, Sun-Mee Leef, Yeong Shik Kimg, Yi-Soo Junga, Antiplatelet effects of Cyperus rotundus and its component(+)-nootkatone, Journal of Ethnopharmacology, 2011; 135: P.48–54.
84.Thebtaranonth C, Antimalarial Sesquiterpenes from Tubers of Rotundus: Structure of 10, 12- Peroxycalamenene, A Sesquiterpene Endoperoxide, Phytocheraistry, 1995; 40(1): P. 125-128.
85.Mulliken Ta (2000) implementing CITES for Himalayan medicinal plants ardostachys grandiflora and picrorhiza kurroa in TRAFFIC Bulletine 18,63-72
86. Zhang YJ, Li W & Zheng M (1994). Chinese-English Chinese Traditional Medicine World Dictionary. Shanxi People’s Press, Shanxi, China.
87. RatheeD, Phytochemical screening & antimicrobial activity of Picrorrhiza kurroa an Indian traditional plant used to treat chronic Diarrhoea. http://dx.doi.org/10.1016.arjc.2012.02.009
88.Kumar PV ,(2010) Invitro Antibactrial Activites of Picrorhiza kurroa Rhizome Extract using well Diffusion method . int J pharm Res 2 (1): 30-30
89. Kumar MH, Antimutagenic activity of root extract of Picrorhiza kurroa using Ames test in both Dose Dependant Cytotoxic Assay & Mutagenicity study pharmacogn phytichem 2(6): 48-52
90..Yamgar S,. Studies on Nephroprotective and Nephrocurative Activity of Ethanolic Extract of Picrorhiza kurroa Royle and Arogyawardhini Bati in Rats. Int J Pharm Technol 2(3): 472-489.
91.Pandey BL (1989). Immunopharmacological Studies on Picrorhiza kurroa Royle ex Benth. Part IV: Cellular Mechanisms of Anti-Inflammatory Action. Indian J Physiol Pharmacol 33(1): 28-30.
92.Sinha S, Bhat J, (2011). Hepatoprotective Activity of Picrorhiza kurroa Royle ex Benth. Extract Against Alcohol Cytotoxicity in Mouse Liver Slice Culture. Int J Green Pharm 5: 244-253.
93. Rajandeep Kaur , kaur et al . IJPSR 2013 vol 4(7) 2470-2477
94.Ilavarasan R., Mallika M. and Venkataraman S., Anti-inflammatory and antioxidant activities of Cassia fistula Linn. Bark extracts. Afr. J. Trad. CAM, 2005; 2 (1): 70 - 85
95. Luximon-Ramma, A., Bahorun, T.. Antioxidant activities of phenolic, proanthocyanidin, and flavonoid components in extracts of Cassia fistula J Agric Food Chem. 2002; 50(18): 5042-5047.
96 . Malpani S.N. et al. Antidiabetic Activity of Cassia fistula Linn Bark in Alloxan Induced Diabetic Rats. Int. J. Phar. Sci. and Res. Jan-April, 2010; 2(1): 382-385
97. Bhakta, T., Banerjee, S., Mandal, S. C., Maity, T. K., Saha, B. P. and Pal, M., Hepatoprotective activity of Cassia fistula leaf extract, Phytomedicine. 2001; 8(3): 220-224.
98 .P. Siddhurajua, P. S. Mohanb and K. Becker. Studies on antioxidant activity of Indian Laburnum (Cassia fistula): a preliminary assessment of crude extracts from stem bark, leaves flowers and fruit pulp. Journal of Food Chemistry, 2001; 79: 61-67.
99 .Manonmania G, Bhavapriyaa V, Kalpanaa S,. Antioxidant activity of Cassia fistula (Linn.) flowers in alloxan induced diabetic rats. Journal of Ethanopharmacology, 2005; 97: 39-42.
100. Desai VB, Pharmacological Screening of HESP & Sandalwood oil. Indian perfumer 1991;69
101 Benencia F , Antiviral activity of sandalwood oil against herpes Simplex 1 & 2 phytomedicine, 1999;6(2):119-123
102. pande MC medicinal oils & importance medicine & surgery 1977; 17:13-16
103 Dikshit A, Antifungal action of some essential oils against animal pathogen Fitoterapia 1984,55:171-176
104. Chavda R, Vadalia KR, Gokani R, Hepatoprotective activity of root bark of Calatropis procera R.Br (Asclepediaceae). Int. J. Pharmacol., 2010; 6(6): 937-934.
105. P.V. Sharma, Dravyagun vigyan, vol- 2, page. 202, Chaukhambha Visvabharati,Reprint 2013
106. P.V. Sharma, Dravyagun vigyan, vol2,page114, Chaukhambha Visvabharati, Reprint -2013.
107. P.V. Sharma, Dravyagun vigyan, vol-2, page697, Chaukhambha Visvabharati, Reprint -2013
108. . P.V. Sharma, Dravyagun vigyan, vol-2,page320, Chaukhambha Visvabharati, Reprint -2013
109. P.V. Sharma, Dravyagun vigyan, vol-2,page443, Chaukhambha Visvabharati, Reprint -2013
110. P.V. Sharma, Dravyagun vigyan, vol-2,page253, Chaukhambha Visvabharati, Reprint -2013
111. P.V. Sharma, Dravyagun vigyan, vol-2,page170, Chaukhambha Visvabharati, Reprint -2013
112. P.V. Sharma, Dravyagun vigyan, vol-2,page715, Chaukhambha Visvabharati, Reprint -2013
113. Priya VratSharma, Susruta Samhita, volume-2,Chikitsa sthana,chapter 40,verse no- 64,Chaukhambha Visvabharati, Varanasi
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